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Albert Hofmann’s first LSD experience

From the late 19th century onward, there was a growing interest in the potential therapeutic benefits of plant-based drugs such as hashish and cannabis. The Swiss pharmaceutical companyhas been around since 1875, aiming to solve the world’s health problems with its patented medicines. On April 16, 1943, one of the company’s chemists, Albert Hofmann, accidentally consumed some of his experimental new medicine while working in his lab. After taking LSD for the first time in history, Hofmann promptly realized how powerful it was and started looking for ways to use it recreationally. So began mankind’s fascination with psychedelic drugs and LSD has been at the forefront ever since.



The Story of Albert Hofmann’s first LSD trip

Albert Hofmann first consumed the potent psychedelic compound on April 16, 1943. He was a 34-year-old German chemist working for the Swiss pharmaceutical company Sandoz. It was a Wednesday, and Hofmann was looking forward to his weekend off with his wife, Anita. Before going out on a boat trip, Hofmann decided to try some of his experimental new medicine, Lysergic Acid Diethylamide (LSD). LSD was a novel compound that Hofmann had been working on for several years. Its main aim was to treat the common cold, but it also had a small potential for use as a recreational drug. Hofmann took a small spoonful of the substance and washed it down with some coffee. He was a little curious to experience the effects of the drug, but was also a little nervous about it as well. LSD is notorious for causing feelings of fear, anxiety, and paranoia. Hofmann had a feeling that it might cause some of those emotions, but he was very curious to see what it would feel like nonetheless. After taking the LSD, Hofmann felt some dizziness and nausea. He decided to lie down on the floor and rest for a while. After a few minutes, the feeling of nausea passed and Hofmann felt better. Once he was feeling better, Hofmann decided to take another spoonful of the LSD and then rejoin his friends on the boat.


LSD’s psychedelic effects

LSD is a powerful psychedelic substance that affects the serotonin neurotransmitter in the brain. Serotonin is a neurotransmitter that acts as a chemical messenger between neurons, generally responsible for regulating mood, sleep, and appetite. The Activation of Serotonin in the Brain During an LSD Trip Why does LSD create psychedelic experiences? The most common effect of LSD on the brain is the generation of a profound feeling of “connectedness” or “oneness” with other people, nature, and the universe. This is exactly the effect the Hofmann was looking for in the LSD he consumed. LSD affects the brain differently in every person, which is why two people can have very different experiences and reactions while they are on the substance. The LSD trip can last between 6 and 12 hours. In between each stage of the psychedelic experience, the person on LSD may feel intense emotions like grief, compassion, inspiration, peace, awe, love, and happiness. After taking LSD, many people report that they feel a greater connection with nature, and may even experience a feeling of “spiritual oneness” with other things like trees, flowers, or the sky.


Hofmann learns about LSD’s capacity to produce mental effects

After his first LSD trip, Hofmann started reading about the drug and its capacity to produce profound changes in the brain. He learned that LSD creates a profound and lasting experience of “connectedness” and “oneness” with everything in the universe. This is exactly what Hofmann experienced during his first LSD trip. He also learned that LSD can cause something called “ego death”, which is a reduced sense of self and the feeling that the person on LSD has “mysterious powers”. After his first experience with LSD, Hofmann understood that this powerful drug has the capacity to generate profound experiences that can change the way a person sees the world forever. LSD is not a drug that makes you feel good, but rather the opposite. It can make you feel intense emotions like grief and sadness, making it a very profound experience.


Hofmann Discovers the Shielding Effect of LSD and creates a synthetic variation of it called “LSD-25”

After his first LSD trip, Hofmann was curious to see if he could repeat the experience. He wanted to know how long the drug would last and how intense the mental effects could be. So he decided to try taking a small spoonful of LSD again. He found that after a few minutes, the effects had worn off again. But then Hofmann decided to try a third spoonful, which prolonged the effects for about 10 minutes. He was hoping that he could get the effects to last longer this time. This is where Hofmann thought of a brilliant idea. Ever since he was a kid, he had always been interested in discovering what substances could produce shielding effects. Shielding effects occur when an exposure to one source of radiation leads to the absence of an unexpected exposure to a different source of radiation. So the next day, Hofmann decided to isolate LSD and create a strong variation of it called “LSD-25”. This modification would help Hofmann sustain the drug’s shield-like effects and produce a more intense psychedelic experience. Hofmann then took another spoonful of LSD and waited for the effects to kick in.


Hofmann Discovers the Role of Serotonin in Psychedelic Experiences

After taking the LSD and waiting for about 10 minutes, Hofmann realized that he could see an effect on the mental levels. As he kept waiting for the effects to kick in, Hofmann started thinking about the work he had to do the next day, like preparing the research chemicals for another study. He also thought about the people he worked with at the pharmaceutical company and realized how interconnected everyone was. It was at that exact moment that Hofmann realized the role of serotonin in the psychedelic experience. Psychedelics like LSD, Psilocybin, and Ayahuasca all act on the serotonin neurotransmitter in the brain. Serotonin is a neurotransmitter that plays a big role in regulating mood, sleep, and hunger. Once Hofmann realized that, he decided to start thinking about the other experiences that serotonin has the potential to produce. For example, he thought about how serotonin is responsible for making someone feel connected with other people. Hofmann started feeling “connected” with other people and things, including the boat he was on.


Flashbacks and Negative Effects from Taking LSD

After Hofmann realized the role of serotonin in psychedelic experiences, he had a few questions about the substance’s effects. What does LSD do in the brain that other drugs don’t? What are the side effects of long-term use? What happens if you binge-take LSD? The first thing that Hofmann discovered after taking LSD was the power of flashbacks. Flashbacks are experiences that feel strikingly familiar to the person on LSD that can be very frightening and confusing for them. For example, Hofmann suddenly had the feeling that he was on a boat with his friend, Felix. Just like Felix, Hofmann felt as though he was on a boat, but this wasn’t the real world. Hofmann also experienced a few negative effects during his LSD binges. One was that he felt very anxious as he was on a boat. There was also a very unpleasant feeling in his stomach that he couldn’t get rid of. Another effect was that he felt like he had “superhuman powers” as he was on LSD.


Should You Take a Bad Trip as an Experience? Or is it dangerous?

After taking LSD for the first time and experiencing the shield-like effects of it, Hofmann decided he wanted to try taking a spoonful again. But Hofmann had changed his mind about the drug since his first experience, and he decided to take a more responsible approach the next time. He decided to take a “good trip” on LSD, meaning he would use a moderate dose and have a positive experience. Good trips on LSD are very different from

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